In this policy brief by the 4P-CAN Project (where ECHAlliance is a partner of), we explore the significant health threat cancer poses in Eastern Europe, where high mortality rates often stem from preventable causes. Despite efforts, primary prevention faces numerous challenges, including low HPV vaccination rates and widespread risk factors such as smoking and obesity. The 4P-CAN project’s living lab in Arges, Romania, stands out as a crucial initiative under the EU Mission on Cancer. It focuses on developing innovative strategies for cancer prevention and can serve as a model for best practices across the region.